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10.1016/j.gene.2020.144969 171 ZhangH.ZhouF.WangY.XieH.LuoS.MengL.et al (2020b)

In contrast, we found that these metabolomic alterations led to a reduction in the plasma level of 66 different metabolites in acute patients versus the R group ( Supplementary Figures 9A-C )

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Ongoing clinical trials test the efficiency of immune system-activating monoclonal antibodies Ipilimumab and Pembrolizumab in melanoma treatment [2, 8, 9]

We used the Preacher and Hayes bootstrapping method, as implemented in the mediation (v4.5.0) R package 75 , using general linear models with sex and country of recruitment as covariates